Effects of Modified Messenger RNA of Adiponectin Delivered by Lipid Nanoparticles on Adipogenesis and Bone Metabolism In Vitro and In Vivo

Keyphrases

• Messenger RNA (mRNA) 100%
• Lipid Nanoparticles 100%
• Adipogenesis 100%
• Adiponectin 100%
• Metabolism in Vitro 100%
• Bone Metabolism 100%
• Obesity 16%
• Bone Healing 16%
• Fracture Model 8%
• Protein Expression 8%
• Inflammatory Response 8%
• Overexpression 8%
• Bone Repair 8%
• White Adipose Tissue 8%
• Diet-induced Obese Mice 8%
• Intravenous Injection 8%
• Histological Analysis 8%
• Preclinical Data 8%
• RAW264.7 Cells 8%
• Matrix metalloproteinase-9 (MMP-9) 8%
• Receptor Activator of nuclear factor-κB Ligand (RANKL) 8%
• Energy Metabolism 8%
• Interleukin-10 8%
• Femur 8%
• Reduced Matrix 8%
• Runt-related Transcription Factor 2 (Runx2) 8%
• MC3T3-E1 Cells 8%
• Related Disorders 8%
• Bone Disease 8%
• Potential Therapeutic Strategies 8%
• Nanoparticle Enhancement 8%
• Adipokines 8%
• Messenger Ribonucleic Acid Expression 8%
• Femoral Fractures 8%
• 3T3-L1 Adipocytes 8%
• Osteogenic Gene Expression 8%
• Computed Tomography Analysis 8%
• Bone Sialoprotein 8%
• Antiresorptive 8%
• Dose-dependent 8%
• Fasting Blood Glucose 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Messenger RNA 100%
• Adiponectin 100%
• Solid Lipid Nanoparticle 100%
• Inflammation 8%
• Receptor 8%
• Diet Induced Obesity 8%
• Femur Fracture 8%
• Gelatinase B 8%
• Nuclear Factor 8%
• Transcription Factor RUNX2 8%
• Interleukin 10 8%
• Bone Disease 8%
• Adipocytokine 8%
• Bone Sialoprotein 8%
• Glucose 8%