Effects of screw configuration on the dissolution behavior of indomethacin in Eudragit® E PO solid disperisons

Huiju Liu, Linjie Zhu, Peng Wang, Xueyan Zhang, Costas G. Gogos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This experimental study examines the evolution of the extent of dissolution of the active pharmaceutical ingredient (API) indomethacin (INM) into the polymer excipient Eudragit® E PO (E PO) on four screw configurations. The Fourier transform infrared spectroscopy (FT-IR) results show that kneading blocks accelerate the complete dissolution process. It is concluded that the kneading blocks, which cause the processed stream to undergo chaotic laminar extensional flow and are crucial to laminar distributive mixing, may be the main necessary mixing elements for the full dissolution of the drug in the polymer melt.

Original languageEnglish (US)
Title of host publication69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Pages1201-1205
Number of pages5
StatePublished - Aug 23 2011
Event69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 - Boston, MA, United States
Duration: May 1 2011May 5 2011

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume2

Other

Other69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
CountryUnited States
CityBoston, MA
Period5/1/115/5/11

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Keywords

  • Dissolution
  • Drug
  • Eudragit® E PO
  • Indomethacin
  • Pharmaceutical
  • Screw configuration
  • Solid dispersions
  • Solid solution

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