Electrodeless electrohydrodynamic drop-on-demand encapsulation of drugs into porous polymer films for fabrication of personalized dosage units

Ezinwa Elele, Yueyang Shen, Ramana Susarla, Boris Khusid, Golshid Keyvan, Bozena Michniak-Kohn

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Noncontact drop-on-demand (DOD) dosing is a promising strategy for manufacturing of personalized dosage units. However, current DOD methods developed for printing chemically and thermally stable, low-viscosity inks are of limited use for pharmaceuticals due to fundamentally different functional requirements. To overcome their deficiency, we developed a novel electrohydrodynamic (EHD) DOD (Appl, Phys, Lett. 97, 233501, 2010) that operates on fluids of up to 30 Pa·s in viscosity over a wide range of droplet sizes and provides a precise control over the droplet volume. We now evaluate the EHD DOD as a method for fabrication of dosage units by printing drug solutions on porous polymer films prepared by freeze-drying. Experiments were carried out on ibuprofen and griseofulvin, as model poorly water-soluble drugs, polyethylene glycol 400, as a drug carrier, and hydroxypropyl methylcellulose films. The similarities between drug release profiles from different dosage units were assessed by model-independent difference, f1, and similarity, f2, factors. The results presented show that EHD DOD offers a powerful tool for the evolving field of small-scale pharmaceutical technologies for tailoring medicines to individual patient's needs by printing a vast array of predefined amounts of therapeutics arranged in a specific pattern on a porous film.copy; 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)2523-2533
Number of pages11
JournalJournal of Pharmaceutical Sciences
Volume101
Issue number7
DOIs
StatePublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Dissolution rate
  • Drug delivery systems
  • Encapsulation
  • Freeze-drying
  • Processing
  • Solid dosage form

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