Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury

Gokhan Ordek; Jonathan D. Groth; Bryan J. Pfister; Mesut Sahin

doi:10.1109/NER.2013.6696098

Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury

Gokhan Ordek, Jonathan D. Groth, Bryan J. Pfister, Mesut Sahin

Bio-Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Cerebellum is highly susceptible to traumatic injuries, and yet it has rarely been studied in the context of traumatic brain injury (TBI). Much of the TBI research in the cerebellum has been conducted through histochemical techniques, particularly using selective protein staining. In this study, we investigated if fluid percussion injury (FPI) was detectable using electrophysiological recordings of the cerebellar activity with multi-contact array electrodes. Rats were chronically implanted with micro ECoG electrodes on the paramedian lobule (PML). The FPI was induced via a skull opening near the electrode implant on the cerebellum. Spontaneous and evoked potentials (EPs) featured almost immediate alterations in their waveform patterns after the delivery of pressure pulse. Recorded evoked potential amplitudes declined drastically by the next day. We also studied the linear correlation changes between all the electrode contact pairs and observed a significant decrease (R from > 0.7 to < 0.4, p <.001) as a result of injury. The results suggest that electrophysiological recording with chronic electrode implants can be used as a method of detection and longitudinal monitoring of subtle effects of TBI in the cerebellar circuits.

Original language	English (US)
Title of host publication	2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Pages	973-976
Number of pages	4
DOIs	https://doi.org/10.1109/NER.2013.6696098
State	Published - 2013
Event	2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States Duration: Nov 6 2013 → Nov 8 2013

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Other

Other	2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Country/Territory	United States
City	San Diego, CA
Period	11/6/13 → 11/8/13

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Mechanical Engineering

Keywords

Cerebellum
Evoked potentials
Micro ECoG
Multi-electrode arrays

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10.1109/NER.2013.6696098

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Ordek, G., Groth, J. D., Pfister, B. J., & Sahin, M. (2013). Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury. In 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 (pp. 973-976). Article 6696098 (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2013.6696098

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title = "Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury",

abstract = "Cerebellum is highly susceptible to traumatic injuries, and yet it has rarely been studied in the context of traumatic brain injury (TBI). Much of the TBI research in the cerebellum has been conducted through histochemical techniques, particularly using selective protein staining. In this study, we investigated if fluid percussion injury (FPI) was detectable using electrophysiological recordings of the cerebellar activity with multi-contact array electrodes. Rats were chronically implanted with micro ECoG electrodes on the paramedian lobule (PML). The FPI was induced via a skull opening near the electrode implant on the cerebellum. Spontaneous and evoked potentials (EPs) featured almost immediate alterations in their waveform patterns after the delivery of pressure pulse. Recorded evoked potential amplitudes declined drastically by the next day. We also studied the linear correlation changes between all the electrode contact pairs and observed a significant decrease (R from > 0.7 to < 0.4, p <.001) as a result of injury. The results suggest that electrophysiological recording with chronic electrode implants can be used as a method of detection and longitudinal monitoring of subtle effects of TBI in the cerebellar circuits.",

keywords = "Cerebellum, Evoked potentials, Micro ECoG, Multi-electrode arrays",

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doi = "10.1109/NER.2013.6696098",

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Ordek, G, Groth, JD, Pfister, BJ & Sahin, M 2013, Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury. in 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013., 6696098, International IEEE/EMBS Conference on Neural Engineering, NER, pp. 973-976, 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013, San Diego, CA, United States, 11/6/13. https://doi.org/10.1109/NER.2013.6696098

Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury. / Ordek, Gokhan; Groth, Jonathan D.; Pfister, Bryan J. et al.
2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013. 2013. p. 973-976 6696098 (International IEEE/EMBS Conference on Neural Engineering, NER).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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N2 - Cerebellum is highly susceptible to traumatic injuries, and yet it has rarely been studied in the context of traumatic brain injury (TBI). Much of the TBI research in the cerebellum has been conducted through histochemical techniques, particularly using selective protein staining. In this study, we investigated if fluid percussion injury (FPI) was detectable using electrophysiological recordings of the cerebellar activity with multi-contact array electrodes. Rats were chronically implanted with micro ECoG electrodes on the paramedian lobule (PML). The FPI was induced via a skull opening near the electrode implant on the cerebellum. Spontaneous and evoked potentials (EPs) featured almost immediate alterations in their waveform patterns after the delivery of pressure pulse. Recorded evoked potential amplitudes declined drastically by the next day. We also studied the linear correlation changes between all the electrode contact pairs and observed a significant decrease (R from > 0.7 to < 0.4, p <.001) as a result of injury. The results suggest that electrophysiological recording with chronic electrode implants can be used as a method of detection and longitudinal monitoring of subtle effects of TBI in the cerebellar circuits.

AB - Cerebellum is highly susceptible to traumatic injuries, and yet it has rarely been studied in the context of traumatic brain injury (TBI). Much of the TBI research in the cerebellum has been conducted through histochemical techniques, particularly using selective protein staining. In this study, we investigated if fluid percussion injury (FPI) was detectable using electrophysiological recordings of the cerebellar activity with multi-contact array electrodes. Rats were chronically implanted with micro ECoG electrodes on the paramedian lobule (PML). The FPI was induced via a skull opening near the electrode implant on the cerebellum. Spontaneous and evoked potentials (EPs) featured almost immediate alterations in their waveform patterns after the delivery of pressure pulse. Recorded evoked potential amplitudes declined drastically by the next day. We also studied the linear correlation changes between all the electrode contact pairs and observed a significant decrease (R from > 0.7 to < 0.4, p <.001) as a result of injury. The results suggest that electrophysiological recording with chronic electrode implants can be used as a method of detection and longitudinal monitoring of subtle effects of TBI in the cerebellar circuits.

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ER -

Electrophysiological monitoring of cerebellar evoked potentials following fluid percussion injury

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