Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications

Deep S. Pandya, Treena Arinzeh, George Collins

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

ECM is useful in providing growth and support to the cells as well as engineered tissues. There are various techniques for producing artificial matrix constructs to simulate the ECM. These include wet spinning, phase separation, dry spinning, and electrospinning. Electrospinning has advantages over other techniques as it can produce scaffolds which have a high surface area to volume ratio. Electrospinning is also capable of producing nanofibers from synthetic polymers as well as from natural polymers Ref [1]. Gelatin has been electrospun from several different solvents Ref. [2]. In this work we have chosen water as the solvent because of its inherent noncytotoxicity. When gelatin is dissolved in water it will form a semi-solid gel. Heating the solution will prevent the formation of gel. Electrospun gel fibers will dissolve in water and physiological fluids. To overcome the gelation, an apparatus has been constructed that allows gel solution to be electrospun at elevated temperature.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - Jun 8 2010
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Publication series

NameProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
CountryUnited States
CityNew York, NY
Period3/26/103/28/10

All Science Journal Classification (ASJC) codes

  • Bioengineering

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