TY - GEN
T1 - Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications
AU - Pandya, Deep S.
AU - Arinzeh, Treena
AU - Collins, George
PY - 2010
Y1 - 2010
N2 - ECM is useful in providing growth and support to the cells as well as engineered tissues. There are various techniques for producing artificial matrix constructs to simulate the ECM. These include wet spinning, phase separation, dry spinning, and electrospinning. Electrospinning has advantages over other techniques as it can produce scaffolds which have a high surface area to volume ratio. Electrospinning is also capable of producing nanofibers from synthetic polymers as well as from natural polymers Ref [1]. Gelatin has been electrospun from several different solvents Ref. [2]. In this work we have chosen water as the solvent because of its inherent noncytotoxicity. When gelatin is dissolved in water it will form a semi-solid gel. Heating the solution will prevent the formation of gel. Electrospun gel fibers will dissolve in water and physiological fluids. To overcome the gelation, an apparatus has been constructed that allows gel solution to be electrospun at elevated temperature.
AB - ECM is useful in providing growth and support to the cells as well as engineered tissues. There are various techniques for producing artificial matrix constructs to simulate the ECM. These include wet spinning, phase separation, dry spinning, and electrospinning. Electrospinning has advantages over other techniques as it can produce scaffolds which have a high surface area to volume ratio. Electrospinning is also capable of producing nanofibers from synthetic polymers as well as from natural polymers Ref [1]. Gelatin has been electrospun from several different solvents Ref. [2]. In this work we have chosen water as the solvent because of its inherent noncytotoxicity. When gelatin is dissolved in water it will form a semi-solid gel. Heating the solution will prevent the formation of gel. Electrospun gel fibers will dissolve in water and physiological fluids. To overcome the gelation, an apparatus has been constructed that allows gel solution to be electrospun at elevated temperature.
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U2 - 10.1109/NEBC.2010.5458180
DO - 10.1109/NEBC.2010.5458180
M3 - Conference contribution
AN - SCOPUS:77953065756
SN - 9781424468799
T3 - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
BT - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
T2 - 36th Annual Northeast Bioengineering Conference, NEBEC 2010
Y2 - 26 March 2010 through 28 March 2010
ER -