Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.

Do Eun Kim, Eun Jung Lee, Timothy P. Martens, Rina Kara, Hina W. Chaudhry, Silviu Itescu, Kevin D. Costa

Research output: Contribution to journalArticlepeer-review

Abstract

For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.

Original languageEnglish (US)
Pages (from-to)849-852
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - Dec 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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