Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.

Do Eun Kim; Eun Jung Lee; Timothy P. Martens; Rina Kara; Hina W. Chaudhry; Silviu Itescu; Kevin D. Costa

Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.

Do Eun Kim
, Eun Jung Lee
, Timothy P. Martens
, Rina Kara
, Hina W. Chaudhry
, Silviu Itescu
, Kevin D. Costa

Research output: Contribution to journal › Article › peer-review

Abstract

For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.

Original language	English (US)
Pages (from-to)	849-852
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
State	Published - Dec 1 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Kim, D. E., Lee, E. J., Martens, T. P., Kara, R., Chaudhry, H. W., Itescu, S., & Costa, K. D. (2006). Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 849-852.

@article{fee1e2fab6c24718bf26d2d174fa6255,

title = "Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.",

abstract = "For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.",

author = "Kim, \{Do Eun\} and Lee, \{Eun Jung\} and Martens, \{Timothy P.\} and Rina Kara and Chaudhry, \{Hina W.\} and Silviu Itescu and Costa, \{Kevin D.\}",

year = "2006",

month = dec,

day = "1",

language = "English (US)",

pages = "849--852",

journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference",

issn = "1557-170X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

Kim, DE, Lee, EJ, Martens, TP, Kara, R, Chaudhry, HW, Itescu, S & Costa, KD 2006, 'Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, pp. 849-852.

Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms. / Kim, Do Eun; Lee, Eun Jung; Martens, Timothy P. et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 01.12.2006, p. 849-852.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.

AU - Kim, Do Eun

AU - Lee, Eun Jung

AU - Martens, Timothy P.

AU - Kara, Rina

AU - Chaudhry, Hina W.

AU - Itescu, Silviu

AU - Costa, Kevin D.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.

AB - For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.

UR - https://www.scopus.com/pages/publications/84903867847

UR - http://www.scopus.com/inward/citedby.url?scp=84903867847&partnerID=8YFLogxK

M3 - Article

C2 - 17946863

SN - 1557-170X

SP - 849

EP - 852

JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ER -

Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this