Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates

M. L. Siriwardane, Bryan Pfister

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Three-dimensional (3D) nervous tissue constructs were developed using a compliant gel matrix and a fiber component for promoting contact-guided axon outgrowth. Rat embryonic (E15) dorsal root ganglion explants (DRGs) were cultured on biodegradable poly-L-lactic acid (PLLA) and wet-spun type I collagen fibers embedded in soft collagen gels. Gel constructs containing fibers induced greater axon outgrowth distances with significantly more directionality along the aligned fibers. Interestingly, wet-spun type I collagen from rat tail tendon displayed a highly aligned outgrowth pattern from DRG axons suggesting potential use for peripheral nerve repair.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - Jun 8 2010
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Publication series

NameProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
CountryUnited States
CityNew York, NY
Period3/26/103/28/10

All Science Journal Classification (ASJC) codes

  • Bioengineering

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