TY - JOUR
T1 - EProbalign
T2 - Generation and manipulation of multiple sequence alignments using partition function posterior probabilities
AU - Chikkagoudar, Satish
AU - Roshan, Usman
AU - Livesay, Dennis
N1 - Funding Information:
We thank system administrators Gedaliah Wolosh and David Perel who have been helpful with technical issues related to the server. DRL is supported, in part, by NIH R01 GM073082-0181. Funding to pay the open access publication charges for this article was provided by startup funding to DRL from the Bioinformatics Research Center at UNC Charlotte.
PY - 2007/7
Y1 - 2007/7
N2 - Probalign computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities. To date, Probalign is among the very best scoring methods on the BAliBASE, HOMSTRAD and OXBENCH benchmarks. Here, we introduce eProbalign, which is an online implementation of the approach. Moreover, the eProbalign web server doubles as an online platform for post-alignment analysis. The heartand-soul of the post-alignment functionality is the Probalign Alignment Viewer applet, which provides users a convenient means to manipulate the alignments by posterior probabilities. The viewer can also be used to produce graphical and text versions of the output. The eProbalign web server and underlying Probalign source code is freely accessible at http://probalign.njit.edu.
AB - Probalign computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities. To date, Probalign is among the very best scoring methods on the BAliBASE, HOMSTRAD and OXBENCH benchmarks. Here, we introduce eProbalign, which is an online implementation of the approach. Moreover, the eProbalign web server doubles as an online platform for post-alignment analysis. The heartand-soul of the post-alignment functionality is the Probalign Alignment Viewer applet, which provides users a convenient means to manipulate the alignments by posterior probabilities. The viewer can also be used to produce graphical and text versions of the output. The eProbalign web server and underlying Probalign source code is freely accessible at http://probalign.njit.edu.
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U2 - 10.1093/nar/gkm267
DO - 10.1093/nar/gkm267
M3 - Article
C2 - 17485479
AN - SCOPUS:34547567393
SN - 0305-1048
VL - 35
SP - W675-W677
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - SUPPL.2
ER -