TY - GEN
T1 - ESSENCE - Cost-effective, universal, modular, electrochemical sensor for rapid, sensitive, and selective detection of DNA, proteins in a low resource setting
AU - Cheng, Yu Hsuan
AU - Zhenglong, Li
AU - Chande, Charmi
AU - Basuray, Sagnik
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The sensor platform, ESSENCE, uses a Shear-Enhanced, flow-through non-planar 3D Nanoporous Electrode to overcomes current electrochemical sensors' selectivity and sensitivity limitations. The porous electrode architecture enhances shear forces (high selectivity), increased convective fluxes that disrupt diffusive processes (rapid measurements) like electric double layer, enhanced electric field penetration with the removal of parasitic noises (high sensitivity). The unique chip architecture allows us to assemble the chip at point-of-use (modular, solving cold chain issues) and target different classes of biomolecules (universal platform). ESSENCE detects DNA and proteins with fM and pg/L sensitivity, respectively, against other background molecules and in undiluted urine.
AB - The sensor platform, ESSENCE, uses a Shear-Enhanced, flow-through non-planar 3D Nanoporous Electrode to overcomes current electrochemical sensors' selectivity and sensitivity limitations. The porous electrode architecture enhances shear forces (high selectivity), increased convective fluxes that disrupt diffusive processes (rapid measurements) like electric double layer, enhanced electric field penetration with the removal of parasitic noises (high sensitivity). The unique chip architecture allows us to assemble the chip at point-of-use (modular, solving cold chain issues) and target different classes of biomolecules (universal platform). ESSENCE detects DNA and proteins with fM and pg/L sensitivity, respectively, against other background molecules and in undiluted urine.
KW - Antigen detection
KW - DNA detection
KW - Electrochemical Sensor
KW - Shear Enhanced Porous Electrode
UR - http://www.scopus.com/inward/record.url?scp=85136975801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136975801&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85136975801
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1505
EP - 1506
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -