Ethanol impairs glucose uptake by human astrocytes and neurons: Protective effects of acetyl-L-carnitine

P. M. Abdul Muneer, Saleena Alikunju, Adam M. Szlachetka, Aaron J. Mercer, James Haorah

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Alcohol consumption causes neurocognitive deficits, neuronal injury, and neurodegeneration. At the cellular level, alcohol abuse causes oxidative damage to mitochondria and cellular proteins and interlink with the progression of neuroinflammation and neurological disorders. We previously reported that alcohol inhibits glucose transport across the blood-brain barrier (BBB), leading to BBB dysfunction and neurodegeneration. In this study, we hypothesized that ethanol (EtOH)-mediated disruption in glucose uptake would deprive energy for human astrocytes and neurons inducing neurotoxicity and neuronal degeneration. EtOH may also have a direct effect on glucose uptake in neurons and astrocytes, which has not been previously described. Our results indicate that ethanol exposure decreases the uptake of D-(2-3H)-glucose by human astrocytes and neurons. Inhibition of glucose uptake correlates with a reduction in glucose transporter protein expression (GLUT1 in astrocytes and GLUT3 in neurons). Acetyl-L-carnitine (ALC), a neuroprotective agent, suppresses the effects of alcohol on glucose uptake and GLUT levels, thus reducing neurotoxicity and neuronal degeneration. These findings suggest that deprivation of glucose in brain cells contributes to neurotoxicity in alcohol abusers, and highlights ALC as a potential therapeutic agent to prevent the deleterious health conditions caused by alcohol abuse.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalInternational Journal of Physiology, Pathophysiology and Pharmacology
Volume3
Issue number1
StatePublished - Jan 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Physiology
  • Physiology (medical)

Keywords

  • Acetyl-L-carnitine
  • Glucose transporter protein
  • Human astrocytes
  • Neurodegeneration

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