Evaluation of foaming of pharmaceutical polymers by CO2 and N2 to enable drug products

Chad D. Brown, Niloufar Faridi, Craig A. McKelvey, John H. Suwardie, Linjie Zhu, Ming Wan Young, Peng Wang, Costas Gogos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Gas mediated foaming of extrudate is of interest to the pharmaceutical industry as a method to improve milling performance, to increase surface area for dissolution of molded parts, and to increase the processing window of thermally labile active ingredients via gas-assist extrusion. Pharmaceutical polymers were characterized via rheology and gas solubility measurements for their ability to support a foamed architecture. Finally, batch foaming studies were conducted and the materials characterized for density and cell size.

Original languageEnglish (US)
Title of host publication69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Pages1224-1228
Number of pages5
StatePublished - Aug 23 2011
Event69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 - Boston, MA, United States
Duration: May 1 2011May 5 2011

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume2

Other

Other69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
CountryUnited States
CityBoston, MA
Period5/1/115/5/11

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Keywords

  • Compounding
  • Foam
  • Injection molding
  • Medical/healthcare

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