Evaluation of O2 and CO2 transfer coefficients in a locally integrated tubular hollow fiber bioreactor

W. Kang, R. Shukla, G. T. Frank, K. K. Sirkar

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4 Scopus citations


We have studied the transfer coefficients for O2 transport to and CO2 removal from a model cell-free system using microporous hydrophobic hollow fibers axially placed along a tubular bioreactor for ethanol production with immobilized yeast in the shell. In this locally integrated bioreactor, O2 and CO2 transfer rates depend strongly on the shell side liquid flow rate; O2 flow rate in the fiber bore influences O2 transport only at very low flow rates. Diffusion of CO2 does not affect O2 transport. Local and overall O2 and CO2 transfer coefficients have been determined for a wide range of Reynolds Numbers. The efficiency of such transfers has been demonstrated for alcohol fermentation.

Original languageEnglish (US)
Pages (from-to)35-51
Number of pages17
JournalApplied Biochemistry and Biotechnology
Issue number1
StatePublished - Aug 1 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology


  • Hollow-fiber
  • carbon dioxide
  • fermentation
  • oxygen
  • transport


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