TY - GEN
T1 - Experimental Validation of a Closed-Loop Respiratory Control Model using Dynamic Clamp
AU - Diekman, Casey O.
AU - Thomas, Peter J.
AU - Wilson, Christopher G.
N1 - Funding Information:
1C. O. Diekman is with the Department of Mathematical Sciences and the Institute for Brain and Neuroscience Research, New Jersey Institute of Technology, Newark, NJ 07102, USA diekman at njit.edu 2P. J. Thomas is with the Department of Mathematics, Applied Mathematics, and Statistics, Department of Biology, Department of Cognitive Science, and Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA pjt9 at case.edu 3C. G. Wilson is with the Center for Perinatal Biology, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA cgwilson at llu.edu This work was supported in part by NSF grants DMS-1413770 and DEB-1654989 to PJT and DMS-1555237 to COD, NIH grants HL-62527 and HL-81622 to CGW, and the Mathematical Biosciences Institute under NSF grant DMS-1440386.
Funding Information:
This work was supported in part by NSF grants DMS-1413770 and DEB-1654989 to PJT and DMS-1555237 to COD, NIH grants HL-62527 and HL-81622 to CGW, and the Mathematical Biosciences Institute under NSF grant DMS-1440386.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/10/26
Y1 - 2018/10/26
N2 - We have previously introduced a model for closed-loop respiratory control incorporating an explicit conductance-based model of bursting pacemaker cells driven by hypoxia sensitive chemosensory feedback. Numerical solution of the model equations revealed two qualitatively distinct asymptotically stable dynamical behaviors: one analogous to regular breathing (eupnea), and a second analogous to pathologically rapid, shallow breathing (tachypnea). As an experimental test of this model, we created a hybrid in vitrolin silico circuit. We used Real Time eXperimental Interface (RTXI) dynamic clamp to incorporate a living pacemaker cell recorded in vitro into a numerical simulation of the closed-loop control model in real time. Here we show that the hybrid circuit can sustain the same bistable behavior as the purely computational model, and we assess the ability of the hybrid circuit to recover from simulated bouts of transient hypoxia.
AB - We have previously introduced a model for closed-loop respiratory control incorporating an explicit conductance-based model of bursting pacemaker cells driven by hypoxia sensitive chemosensory feedback. Numerical solution of the model equations revealed two qualitatively distinct asymptotically stable dynamical behaviors: one analogous to regular breathing (eupnea), and a second analogous to pathologically rapid, shallow breathing (tachypnea). As an experimental test of this model, we created a hybrid in vitrolin silico circuit. We used Real Time eXperimental Interface (RTXI) dynamic clamp to incorporate a living pacemaker cell recorded in vitro into a numerical simulation of the closed-loop control model in real time. Here we show that the hybrid circuit can sustain the same bistable behavior as the purely computational model, and we assess the ability of the hybrid circuit to recover from simulated bouts of transient hypoxia.
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U2 - 10.1109/EMBC.2018.8513424
DO - 10.1109/EMBC.2018.8513424
M3 - Conference contribution
C2 - 30441527
AN - SCOPUS:85056671077
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5273
EP - 5276
BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Y2 - 18 July 2018 through 21 July 2018
ER -