Experimentally-Validated Micromixing-Based CFD Model for Feld-Batch Stirred-Tank Reactors

Otute Akiti, Piero M. Armenante

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A model was developed to predict the final product distribution in fed-batch, stirred-tank reactors carrying out fast, parallel, chemical reactions, and the predictions were compared with experimental data. The following reaction system was chosen: A + B →k1 P + R A + C →k2 Q + S Comparison between the experimentally determined flow field inside the reactor, obtained with a laser-doppler velocimeter (LDV), and the predictions from computational fluid dynamics (CFD) simulations was favorable. A model was developed to predict the yield, Xs, of forming S from A, using CFD to describe the velocity distribution inside the reactor, two micromixing models to represent the interaction between turbulence effects and chemical reactions, and a multiphase model (Volume of Fluid (VOF) model) to track the reacting zone in a Lagrangian fashion, Model predictions for Xs were compared with experimental data, The agreement between the experiments and the results of the simulations was good.

Original languageEnglish (US)
Pages (from-to)566-577
Number of pages12
JournalAIChE Journal
Issue number3
StatePublished - Mar 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Environmental Engineering
  • General Chemical Engineering


  • CFD
  • Competitive reactions
  • Fed-batch reactor
  • LDV
  • Micromixing


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