TY - JOUR
T1 - Exploring tablet design options for tailoring drug release and dose via fused deposition modeling (FDM) 3D printing
AU - Gorkem Buyukgoz, Guluzar
AU - Soffer, David
AU - Defendre, Jackenson
AU - Pizzano, Gia M.
AU - Davé, Rajesh N.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - The aim of this paper was to explore tablet design options for FDM 3D printing for simultaneous tailoring of drug release and dose. The drug, griseofulvin (GF), the polymer, hydroxypropyl cellulose (HPC), and processing temperatures were selected to avoid confounding effects arising from drug-polymer interactions. Filaments containing 0–30 wt% GF were prepared using a twin-screw extruder. Five tablet designs were printed using combinations of fixed or varying drug-concentration filaments, fixed or varying tablet sizes, or placebo and drug-rich regions. Two of five options met the main objective; varying drug-concentration filaments for fixed tablet size or printing fixed size duo-tablet having internal placebo regions of varying sizes. Analysis of the drug dissolution profiles revealed that the tablet surface area to volume (SA/V) ratio was the dominant factor, a higher SA/V ratio resulted in a faster release rate, mostly independent of the drug amount or its placement within the tablet. Use of HPC led to near zero-order release for most cases. For duo-tablets, long lag times proportional to placebo shell-thickness were observed. These results suggest that design options other than varying the tablet size would be needed to achieve desired drug release from FDM-based 3D printed personalized dosages.
AB - The aim of this paper was to explore tablet design options for FDM 3D printing for simultaneous tailoring of drug release and dose. The drug, griseofulvin (GF), the polymer, hydroxypropyl cellulose (HPC), and processing temperatures were selected to avoid confounding effects arising from drug-polymer interactions. Filaments containing 0–30 wt% GF were prepared using a twin-screw extruder. Five tablet designs were printed using combinations of fixed or varying drug-concentration filaments, fixed or varying tablet sizes, or placebo and drug-rich regions. Two of five options met the main objective; varying drug-concentration filaments for fixed tablet size or printing fixed size duo-tablet having internal placebo regions of varying sizes. Analysis of the drug dissolution profiles revealed that the tablet surface area to volume (SA/V) ratio was the dominant factor, a higher SA/V ratio resulted in a faster release rate, mostly independent of the drug amount or its placement within the tablet. Use of HPC led to near zero-order release for most cases. For duo-tablets, long lag times proportional to placebo shell-thickness were observed. These results suggest that design options other than varying the tablet size would be needed to achieve desired drug release from FDM-based 3D printed personalized dosages.
KW - 3D printing
KW - Duo-tablets
KW - Fused deposition modeling (FDM)
KW - Personalized drug dose
KW - Surface area to volume ratio
KW - Tablet design
KW - Tailored drug release
UR - http://www.scopus.com/inward/record.url?scp=85092732899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092732899&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2020.119987
DO - 10.1016/j.ijpharm.2020.119987
M3 - Article
C2 - 33069894
AN - SCOPUS:85092732899
SN - 0378-5173
VL - 591
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 119987
ER -