Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery

Zhaoxiong Wan, Shupei Yu, Qi Wang, Karthik Sambath, Roshena Harty, Xiangshan Liu, Hao Chen, Chen Wang, Xuan Liu, Yuanwei Zhang

Research output: Contribution to journalArticlepeer-review


Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

Original languageEnglish (US)
Pages (from-to)9889-9893
Number of pages5
JournalJournal of Materials Chemistry B
Issue number41
StatePublished - Oct 18 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science


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