Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery

Zhaoxiong Wan; Shupei Yu; Qi Wang; Karthik Sambath; Roshena Harty; Xiangshan Liu; Hao Chen; Chen Wang; Xuan Liu; Yuanwei Zhang

doi:10.1039/d3tb01867a

Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery

Zhaoxiong Wan
, Shupei Yu
, Qi Wang
, Karthik Sambath
, Roshena Harty
, Xiangshan Liu
, Hao Chen
, Chen Wang
, Xuan Liu
, Yuanwei Zhang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a ¹H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

Original language	English (US)
Pages (from-to)	9889-9893
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	11
Issue number	41
DOIs	https://doi.org/10.1039/d3tb01867a
State	Published - Oct 18 2023

All Science Journal Classification (ASJC) codes

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/d3tb01867a

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title = "Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery",

abstract = "Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.",

author = "Zhaoxiong Wan and Shupei Yu and Qi Wang and Karthik Sambath and Roshena Harty and Xiangshan Liu and Hao Chen and Chen Wang and Xuan Liu and Yuanwei Zhang",

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doi = "10.1039/d3tb01867a",

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TY - JOUR

T1 - Far-red BODIPY-based oxime esters

T2 - photo-uncaging and drug delivery

AU - Wan, Zhaoxiong

AU - Yu, Shupei

AU - Wang, Qi

AU - Sambath, Karthik

AU - Harty, Roshena

AU - Liu, Xiangshan

AU - Chen, Hao

AU - Wang, Chen

AU - Liu, Xuan

AU - Zhang, Yuanwei

PY - 2023/10/18

Y1 - 2023/10/18

N2 - Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

AB - Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

UR - https://www.scopus.com/pages/publications/85175267835

UR - https://www.scopus.com/pages/publications/85175267835#tab=citedBy

U2 - 10.1039/d3tb01867a

DO - 10.1039/d3tb01867a

M3 - Article

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AN - SCOPUS:85175267835

SN - 2050-750X

VL - 11

SP - 9889

EP - 9893

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 41

ER -

Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery

Abstract

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