Fibrous scaffolds for bone tissue engineering

Jennifer Moy, Apurva Limaye, Treena Livingston Arinzeh

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation. This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.

Original languageEnglish (US)
Title of host publicationArtificial Protein and Peptide Nanofibers
Subtitle of host publicationDesign, Fabrication, Characterization, and Applications
PublisherElsevier
Pages351-382
Number of pages32
ISBN (Electronic)9780081028506
DOIs
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Materials Science(all)

Keywords

  • Bone
  • Electrospinning
  • Fibers
  • Mesenchymal stem cells
  • Wet spinning

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