Fibrous scaffolds for bone tissue engineering

Jennifer Moy; Apurva Limaye; Treena Livingston Arinzeh

doi:10.1016/B978-0-08-102850-6.00015-2

Fibrous scaffolds for bone tissue engineering

Jennifer Moy, Apurva Limaye, Treena Livingston Arinzeh

Bio-Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation. This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.

Original language	English (US)
Title of host publication	Artificial Protein and Peptide Nanofibers
Subtitle of host publication	Design, Fabrication, Characterization, and Applications
Publisher	Elsevier
Pages	351-382
Number of pages	32
ISBN (Electronic)	9780081028506
DOIs	https://doi.org/10.1016/B978-0-08-102850-6.00015-2
State	Published - Jan 1 2020

All Science Journal Classification (ASJC) codes

General Engineering
General Materials Science

Keywords

Bone
Electrospinning
Fibers
Mesenchymal stem cells
Wet spinning

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10.1016/B978-0-08-102850-6.00015-2

Cite this

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abstract = "More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation. This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.",

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AU - Arinzeh, Treena Livingston

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AB - More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation. This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.

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KW - Electrospinning

KW - Fibers

KW - Mesenchymal stem cells

KW - Wet spinning

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Fibrous scaffolds for bone tissue engineering

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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