Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

Arun Reddy Ravula, Suraj Benerji Teegala, Shanker Kalakotla, Jagadeesh Prasad Pasangulapati, Venkatesan Perumal, Hemanth Kumar Boyina

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Neurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several fruits and vegetables. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. Parkinson's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Stroke, Traumatic Brain Injury (TBI), and age-associated changes. This review aimed to evaluate the potential mechanisms and pharmacological effects of fisetin in treating several neurological diseases. This review also provides comprehensive data on up-to-date recent literature and highlights the various mechanistic pathways pertaining to fisetin's neuroprotective role.

Original languageEnglish (US)
Article number174492
JournalEuropean Journal of Pharmacology
StatePublished - Nov 5 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


  • Acetyl CoA
  • CREB
  • Keap 1
  • NAD+
  • NF-κB
  • Sirtuin


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