Formation of polymer nano-particles in supercritical fluid jets

A. Gokhale, B. Khusid, R. Dave, R. Pfeffer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

The supercritical antisolvent (SAS) process is an emerging technology for the production of micro- and nanometer-sized particles for a wide variety of bio-medical pharmaceutical applications [1]. In this paper, polyvinylpyrrolidone (PVP) nanoparticles are synthesized using dichloromethane (DCM) and acetone as organic solvents to prepare polymer solution and carbon dioxide in supercritical phase is used as an antisolvent. Several capillary nozzles from 20 μm to 127 μm are used to inject the solution at different Reynolds number. Particles from sub-micron size to nano size are obtained depending upon operating parameters.

Original languageEnglish (US)
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages215-217
Number of pages3
StatePublished - Dec 1 2005
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: May 8 2005May 12 2005

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Other

Other2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
CountryUnited States
CityAnaheim, CA
Period5/8/055/12/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Keywords

  • Biopolymers
  • Nanoparticles
  • Polyvinylpyrrolidone
  • Supercritical Fluids

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