Functional connectivity of vergence neural substrates

R. Jaswal, Suril Gohel, Bharat B. Biswal, Tara L. Alvarez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


While fMRI has identified which regions of interests (ROI) are functionally active during a vergence task (the inward or outward rotation of eyes), the functional connectivity between ROIs is less understood. This study tested the following hypotheses: 1) significant functional connectivity would be observed between the frontal eye fields (FEF), the posterior parietal cortex (PPC) and the cerebellar vermis (CV), 2) significantly more functional activity and connectivity would be observed in binocularly normal controls (BNC) compared to patients with convergence insufficiency (CI), and 3) after vergence training, the functional activity and connectivity would improve in CI subjects compared to their baseline measurements. A block design of sustained fixation versus vergence eye movements stimulated activity in the FEF, PPC and CV. FMRI data from four CI subjects before and after vergence training were compared to seven BNC. Functional activity was assessed using the BOLD percent signal change. Functional connectivity was assessed using a seed-based functional connectivity analysis, which revealed significant correlation between the FEF, PPC and CV ROIs.

Original languageEnglish (US)
Title of host publicationProceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479937288
StatePublished - Dec 2 2014
Event2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 - Boston, United States
Duration: Apr 25 2014Apr 27 2014

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001


Other2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
Country/TerritoryUnited States

All Science Journal Classification (ASJC) codes

  • Bioengineering


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