Functional reorganization in thalamocortical networks: Transition between spindling and delta sleep rhythms

D. Terman, A. Bose, N. Kopell

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Thalamic reticularis, thalamocortical, and cortical cells participate in the 7-14-hz spindling rhythm of early sleep and the slower delta rhythms of deeper sleep, with different firing patterns. In this case study, showing the interactions of intrinsic and synaptic properties, a change in the conductance of one kind of cell effectively rewires the thalamocortical circuit, leading to the transition from the spindling to the delta rhythm. The two rhythms make different uses of the fast (GABA(A)) and slow (GABA(B)) inhibition generated by the thalamic reticularis cells.

Original languageEnglish (US)
Pages (from-to)15417-15422
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number26
DOIs
StatePublished - Dec 24 1996

All Science Journal Classification (ASJC) codes

  • General

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