Functions and Roles of a Protein-Associated Factor

Md Mosharrof Hossain Sarker, Meng Chu Zhou, Pranela Rameshwar, John A. Hanover

Research output: Contribution to journalArticlepeer-review


Abstract: The divergence of protein (Hedgehog) in different organisms remains an unresolved issue to comprehend how the pathway in Hh signaling evolves. Insights into this question can help one identify the key molecules in Hh signaling. This work proposes a protein-associated factor in cells. The development of a non-reductionist theory of cellular functions in medicine is not sufficient. It is necessary to find the parameters with regards to molecules/genes that can elicit functions. This work shows that molecular interactions of gene products can be accomplished by biophysics logic. Defining the protein-associated factors in molecular activities and identifying its roles in molecular transduction are important. A misregulation in molecular switch can account for complex biomolecular consequences. This work shows the potential of the factor on homo-sapiens and unlocks its implications to gene multi-tasking functionality. The associated factor notion should facilitate the medical development in cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalCell Biochemistry and Biophysics
Issue number3
StatePublished - Apr 2014

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Cell Biology


  • Associated factor
  • Signal guide
  • Stem cells


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