Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

Gijs Van Ingen; Jin Li; Andre Goedegebure; Rahul Pandey; Yun Rose Li; Michael E. March; Vincent W.V. Jaddoe; Marina Bakay; Frank D. Mentch; Kelly Thomas; Zhi Wei; Xiao Chang; Heather S. Hain; Andre G. Uitterlinden; Henriette A. Moll; Cornelia M. Van Duijn; Fernando Rivadeneira; Hein Raat; Robert J.Baatenburg De Jong; Patrick M. Sleiman; Marc P. Van Der Schroeff; Hakon Hakonarson

doi:10.1038/ncomms12792

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

Gijs Van Ingen, Jin Li, Andre Goedegebure, Rahul Pandey, Yun Rose Li, Michael E. March, Vincent W.V. Jaddoe, Marina Bakay, Frank D. Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S. Hain, Andre G. Uitterlinden, Henriette A. Moll, Cornelia M. Van Duijn, Fernando Rivadeneira, Hein Raat, Robert J.Baatenburg De Jong, Patrick M. SleimanMarc P. Van Der Schroeff, Hakon Hakonarson

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30 Scopus citations

Abstract

Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, P_meta=2.15 × 10^-09), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10^-06), and further show it is an eQTL for FNDC1 (P=9.3 × 10^-05). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.

Original language	English (US)
Article number	12792
Journal	Nature communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms12792
State	Published - Sep 28 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/ncomms12792

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Van Ingen, G., Li, J., Goedegebure, A., Pandey, R., Rose Li, Y., March, M. E., Jaddoe, V. W. V., Bakay, M., Mentch, F. D., Thomas, K., Wei, Z., Chang, X., Hain, H. S., Uitterlinden, A. G., Moll, H. A., Van Duijn, C. M., Rivadeneira, F., Raat, H., De Jong, R. J. B., ... Hakonarson, H. (2016). Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nature communications, 7, Article 12792. https://doi.org/10.1038/ncomms12792

@article{8df88772306e4d5f8bf764c6793d92f6,

title = "Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene",

abstract = "Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2.15 × 10-09), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10-06), and further show it is an eQTL for FNDC1 (P=9.3 × 10-05). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.",

author = "{Van Ingen}, Gijs and Jin Li and Andre Goedegebure and Rahul Pandey and {Rose Li}, Yun and March, {Michael E.} and Jaddoe, {Vincent W.V.} and Marina Bakay and Mentch, {Frank D.} and Kelly Thomas and Zhi Wei and Xiao Chang and Hain, {Heather S.} and Uitterlinden, {Andre G.} and Moll, {Henriette A.} and {Van Duijn}, {Cornelia M.} and Fernando Rivadeneira and Hein Raat and {De Jong}, {Robert J.Baatenburg} and Sleiman, {Patrick M.} and {Van Der Schroeff}, {Marc P.} and Hakon Hakonarson",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.",

year = "2016",

month = sep,

day = "28",

doi = "10.1038/ncomms12792",

language = "English (US)",

volume = "7",

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Van Ingen, G, Li, J, Goedegebure, A, Pandey, R, Rose Li, Y, March, ME, Jaddoe, VWV, Bakay, M, Mentch, FD, Thomas, K, Wei, Z, Chang, X, Hain, HS, Uitterlinden, AG, Moll, HA, Van Duijn, CM, Rivadeneira, F, Raat, H, De Jong, RJB, Sleiman, PM, Van Der Schroeff, MP & Hakonarson, H 2016, 'Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene', Nature communications, vol. 7, 12792. https://doi.org/10.1038/ncomms12792

TY - JOUR

T1 - Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

AU - Van Ingen, Gijs

AU - Li, Jin

AU - Goedegebure, Andre

AU - Pandey, Rahul

AU - Rose Li, Yun

AU - March, Michael E.

AU - Jaddoe, Vincent W.V.

AU - Bakay, Marina

AU - Mentch, Frank D.

AU - Thomas, Kelly

AU - Wei, Zhi

AU - Chang, Xiao

AU - Hain, Heather S.

AU - Uitterlinden, Andre G.

AU - Moll, Henriette A.

AU - Van Duijn, Cornelia M.

AU - Rivadeneira, Fernando

AU - Raat, Hein

AU - De Jong, Robert J.Baatenburg

AU - Sleiman, Patrick M.

AU - Van Der Schroeff, Marc P.

AU - Hakonarson, Hakon

PY - 2016/9/28

Y1 - 2016/9/28

N2 - Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2.15 × 10-09), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10-06), and further show it is an eQTL for FNDC1 (P=9.3 × 10-05). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.

AB - Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2.15 × 10-09), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10-06), and further show it is an eQTL for FNDC1 (P=9.3 × 10-05). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.

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DO - 10.1038/ncomms12792

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SN - 2041-1723

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JO - Nature communications

JF - Nature communications

M1 - 12792

ER -

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

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