Abstract
Motif finding in DNA, RNA and proteins plays an important role in life science research. In this paper, we present a computational approach to searching for RNA tertiary motifs in genomic sequences. Specifically, we describe a method, named CSminer, and show, as a case study, the application of CSminer to genome-wide search for coaxial helical stackings in RNA 3-way junctions. A coaxial helical stacking motif occurs in an RNA 3-way junction where two separate helical elements form a pseudocontiguous helix and provide thermodynamic stability to the RNA molecule as a whole. Experimental results demonstrate the effectiveness of our approach.
Original language | English (US) |
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Title of host publication | IEEE 12th International Conference on BioInformatics and BioEngineering, BIBE 2012 |
Pages | 260-265 |
Number of pages | 6 |
DOIs | |
State | Published - Dec 1 2012 |
Event | 12th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2012 - Larnaca, Cyprus Duration: Nov 11 2012 → Nov 13 2012 |
Other
Other | 12th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2012 |
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Country | Cyprus |
City | Larnaca |
Period | 11/11/12 → 11/13/12 |
All Science Journal Classification (ASJC) codes
- Bioengineering
- Biomedical Engineering