Abstract
A graphical procedure was proposed for the optimum design of transdermal drug-delivery systems enhanced by iontophoresis. Contour plots displayed the relationships among steady-state plasma level, current density and initial drug concentration in a vehicle. This information was combined with a closed-form expression of the process time constant, estimated as the medicament in the blood reaches a plateau after application of the electric field. Analysis was conducted using Laplace-transformed variables and did not require time-domain solutions. Simulation results show that a current density of 0.044mA/cm2 and a loading of 3500μg/ml of dexamethasone sodium m-sulfobenzoate were necessary to achieve an equilibrium plasma concentration of 1.254ng/cm3 with a time constant of 8.34h.
Original language | English (US) |
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Pages (from-to) | 447-455 |
Number of pages | 9 |
Journal | Computer Methods and Programs in Biomedicine |
Volume | 107 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2012 |
All Science Journal Classification (ASJC) codes
- Software
- Computer Science Applications
- Health Informatics
Keywords
- Iontophoresis
- Membrane transport
- Optimum design
- Simulations
- Time constant
- Transdermal drug delivery