TY - JOUR
T1 - High-frequency, depressing inhibition facilitates synchronization in globally inhibitory networks
AU - Kunec, S.
AU - Bose, A.
N1 - Funding Information:
We thank Gyorgy Buzsaki for many helpful discussions which spurred our initial interest in this problem and shaped our approach to it. We also thank the referees for valuable comments and suggestions which helped improve this paper. This research was supported by a grant from the National Science Foundation (DMS-9973230) and by the Burroughs-Wellcome Fund (no 1001749).
PY - 2003/11
Y1 - 2003/11
N2 - Motivated by the study of sharp wave-associated ripples, high-frequency (∼200 Hz) extracellular field oscillations observed in the CA1 region of the rat hippocampus during slow-wave sleep and periods of behavioural immobility, we consider a single inhibitory neuron synapsing onto a network of uncoupled, excitatory neurons. The inhibitory synapse is depressing and has a small synaptic delay. Each excitatory cell provides instantaneous, positive feedback to the inhibitory cell. We show that the interneuron can rapidly synchronize the action potentials of the pyramidal cells if the frequency of inhibitory input is increased in a ramp-like manner as occurs during the ripple. We show that the basin of attraction of the synchronous solution is larger when the inhibition frequency is gradually increased as opposed to remaining constant.
AB - Motivated by the study of sharp wave-associated ripples, high-frequency (∼200 Hz) extracellular field oscillations observed in the CA1 region of the rat hippocampus during slow-wave sleep and periods of behavioural immobility, we consider a single inhibitory neuron synapsing onto a network of uncoupled, excitatory neurons. The inhibitory synapse is depressing and has a small synaptic delay. Each excitatory cell provides instantaneous, positive feedback to the inhibitory cell. We show that the interneuron can rapidly synchronize the action potentials of the pyramidal cells if the frequency of inhibitory input is increased in a ramp-like manner as occurs during the ripple. We show that the basin of attraction of the synchronous solution is larger when the inhibition frequency is gradually increased as opposed to remaining constant.
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U2 - 10.1088/0954-898X_14_4_303
DO - 10.1088/0954-898X_14_4_303
M3 - Article
C2 - 14653497
AN - SCOPUS:0346365200
SN - 0954-898X
VL - 14
SP - 647
EP - 672
JO - Network: Computation in Neural Systems
JF - Network: Computation in Neural Systems
IS - 4
ER -