Hollow fiber solvent extraction of pharmaceutical products: A case study

R. Prasad, K. K. Sirkar

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Dispersion-free solvent extraction using Celgard® microporous hydrophobic hollow fibers and flat membranes has been utilized for extraction/purification of fermentation-based pharmaceutical products. Extraction as well as back extraction has been studied using a pH swing procedure. Problems of emulsion formation, inherent in current processes, have been avoided to obtain stable dispersion-free operation. Very high solute recoveries and mass transfer rates have been obtained in the hollow fiber devices. Modular plant design using a series-parallel arrangement of this type of extractors and cost of existing dispersion-based devices indicate that these novel devices can compete effectively with commercial extractors.

Original languageEnglish (US)
Pages (from-to)235-259
Number of pages25
JournalJournal of Membrane Science
Volume47
Issue number3
DOIs
StatePublished - Dec 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation

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