Abstract
Dispersion-free solvent extraction using Celgard® microporous hydrophobic hollow fibers and flat membranes has been utilized for extraction/purification of fermentation-based pharmaceutical products. Extraction as well as back extraction has been studied using a pH swing procedure. Problems of emulsion formation, inherent in current processes, have been avoided to obtain stable dispersion-free operation. Very high solute recoveries and mass transfer rates have been obtained in the hollow fiber devices. Modular plant design using a series-parallel arrangement of this type of extractors and cost of existing dispersion-based devices indicate that these novel devices can compete effectively with commercial extractors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-259 |
| Number of pages | 25 |
| Journal | Journal of Membrane Science |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1989 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- General Materials Science
- Physical and Theoretical Chemistry
- Filtration and Separation