TY - GEN
T1 - Hot melt mixing of indomethacin and Soluplus® for oral delivery
AU - Terife, G.
AU - Gogos, C. G.
AU - Wang, P.
PY - 2011
Y1 - 2011
N2 - An amorphous solid suspension for oral drug delivery was prepared via Hot Melt mixing 30wt% of Indomethacin (INM) with Soluplus® (polymeric excipient). The melt mixed sample was characterized through optical microscopy, DSC, FR-IR and XRD. Dissolution test showed that INM release was pH-dependent; in the case of the amorphous solid suspension within 1h 90% of INM was released at pH7.4, while only 0.02% at pH1.2, probably a consequence of hydrogen bonds formed between INM and the polymer. The fastest release was obtained from the foamed amorphous solid suspension, followed by un-foamed amorphous solid suspension, then pure INM and finally the physical mixture.
AB - An amorphous solid suspension for oral drug delivery was prepared via Hot Melt mixing 30wt% of Indomethacin (INM) with Soluplus® (polymeric excipient). The melt mixed sample was characterized through optical microscopy, DSC, FR-IR and XRD. Dissolution test showed that INM release was pH-dependent; in the case of the amorphous solid suspension within 1h 90% of INM was released at pH7.4, while only 0.02% at pH1.2, probably a consequence of hydrogen bonds formed between INM and the polymer. The fastest release was obtained from the foamed amorphous solid suspension, followed by un-foamed amorphous solid suspension, then pure INM and finally the physical mixture.
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M3 - Conference contribution
AN - SCOPUS:80051822141
SN - 9781617829604
T3 - Annual Technical Conference - ANTEC, Conference Proceedings
SP - 1253
EP - 1258
BT - 69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
T2 - 69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Y2 - 1 May 2011 through 5 May 2011
ER -