Hot melt mixing of indomethacin and Soluplus® for oral delivery

G. Terife, C. G. Gogos, P. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An amorphous solid suspension for oral drug delivery was prepared via Hot Melt mixing 30wt% of Indomethacin (INM) with Soluplus® (polymeric excipient). The melt mixed sample was characterized through optical microscopy, DSC, FR-IR and XRD. Dissolution test showed that INM release was pH-dependent; in the case of the amorphous solid suspension within 1h 90% of INM was released at pH7.4, while only 0.02% at pH1.2, probably a consequence of hydrogen bonds formed between INM and the polymer. The fastest release was obtained from the foamed amorphous solid suspension, followed by un-foamed amorphous solid suspension, then pure INM and finally the physical mixture.

Original languageEnglish (US)
Title of host publication69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
Pages1253-1258
Number of pages6
StatePublished - Aug 23 2011
Event69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011 - Boston, MA, United States
Duration: May 1 2011May 5 2011

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume2

Other

Other69th Annual Technical Conference of the Society of Plastics Engineers 2011, ANTEC 2011
CountryUnited States
CityBoston, MA
Period5/1/115/5/11

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

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