Identification of a novel spinal nociceptive-motor gate control for aδ pain stimuli in rats

Dvir Blivis, Gal Haspel, Philip Z. Mannes, Michael J. O’Donovan, Michael J. Iadarola

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. Here, high-speed videography during nociceptive Ad fiber stimulation demonstrated engagement of a multi-segmental motor program coincident with, or even preceding, withdrawal of the stimulated paw. The motor program included early head orientation and adjustments of the torso and un-stimulated paws. Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hindlimbs and which was partially dependent on the endogenous opioid system. These data reveal a profound, immediate and precise integration of nociceptive inputs with ongoing motor activities leading to the initiation of complex, yet behaviorally appropriate, response patterns and the mobilization of a new type of analgesic mechanism within this early temporal nociceptive window.

Original languageEnglish (US)
Article numbere23584
StatePublished - May 24 2017

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Identification of a novel spinal nociceptive-motor gate control for aδ pain stimuli in rats'. Together they form a unique fingerprint.

Cite this