Identification of critical molecules via fault diagnosis engineering

Ali Abdi, Mehdi B. Tahoori, Effat S. Emamian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Systems biology envisions that the application of complex system engineering approaches to cell signaling molecular networks can lead to novel understandings of complex human disorders. In this paper we show that by developing biologically-driven vulnerability assessment methods, the vulnerability of complex signaling networks to the dysfunction of each molecule can be determined. We have analyzed signaling networks that regulate mitosis and the activity of the transcription factor CREB. Our results indicate that biologically-relevant critical components of intracellular molecular networks can be identified using the proposed systems biology/fault diagnosis engineering technique. The application of this approach can improve our physiological understanding of the functionality of biological systems, can be used as a tool to identify novel genes associated with complex human disorders, and ultimately, has the potential to find the most prominent targets for drug discovery.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages4898-4901
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Jan 1 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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