Identifying the true origins of selectivity in chiral phosphoric acid catalyzed: N -acyl-azetidine desymmetrizations

Keyphrases

• Acyl 100%
• Desymmetrization 100%
• Chiral Phosphoric Acid 100%
• Acid-catalyzed 100%
• Azetidine 100%
• Transition Structure 75%
• Toluene 50%
• Nucleophile 50%
• Noncovalent Interactions 25%
• Structure Optimization 25%
• Density Functional Calculations 25%
• Reaction Mechanism 25%
• Energy Difference 25%
• Phosphoric Acid 25%
• Tautomers 25%
• High Enantioselectivity 25%
• Benzoyl 25%
• Activation Mode 25%
• Bifunctional Activation 25%
• Conformational Sampling 25%
• Free Energy Difference 25%
• Phosphoric Acid Catalyst 25%
• Steric Map 25%
• 2-mercaptobenzothiazole 25%
• Orbital Interaction 25%
• BINOL 25%
• Transition Complex 25%
• Thione 25%
• Model Catalyst 25%
• Chiral Catalyst 25%

Chemistry

• Phosphoric Acid 100%
• Azetidine 100%
• Nucleophile 50%
• Non-Covalent Interactions 25%
• Density Functional Theory 25%
• Gibbs Free Energy 25%
• Tautomer 25%
• Acid Catalyst 25%
• Enantioselectivity 25%
• Benzoyl Group 25%

Material Science

• Nucleophile 100%
• Density 50%