Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials

Yuanwei Zhang; Ling Huang; Zhanjun Li; Guolin Ma; Yubin Zhou; Gang Han

doi:10.1021/acsnano.6b02284

Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials

Yuanwei Zhang
, Ling Huang
, Zhanjun Li
, Guolin Ma
, Yubin Zhou
, Gang Han

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

The regulation of cellular signaling in vivo has been a challenging task owing to the lack of effective methods for tunable control of the amplitude, location, and duration of cell-signaling events at a deep-tissue level. In this issue of ACS Nano, an intriguing paper by Ambrosone et al. demonstrates that deep-tissue-penetrating near-infrared (NIR) light can be used to control the Wnt/β-catenin-signaling pathway in a single-cell organism (Hydra) by utilizing microcapsules that contain plasmonic gold nanoparticles. In parallel, in recent work, we proposed upconversion nanoparticles (UCNPs) as NIR-light-activatable "wireless" optogenetic tools, and we showed their ability to modulate cell signaling pathways in both mammalian cells and mice. We believe that these interesting NIR-light-responsive nanotechnologies will open new avenues for both basic research and clinical applications.

Original language	English (US)
Pages (from-to)	3881-3885
Number of pages	5
Journal	ACS Nano
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/acsnano.6b02284
State	Published - Apr 26 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/acsnano.6b02284

Cite this

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title = "Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials",

abstract = "The regulation of cellular signaling in vivo has been a challenging task owing to the lack of effective methods for tunable control of the amplitude, location, and duration of cell-signaling events at a deep-tissue level. In this issue of ACS Nano, an intriguing paper by Ambrosone et al. demonstrates that deep-tissue-penetrating near-infrared (NIR) light can be used to control the Wnt/β-catenin-signaling pathway in a single-cell organism (Hydra) by utilizing microcapsules that contain plasmonic gold nanoparticles. In parallel, in recent work, we proposed upconversion nanoparticles (UCNPs) as NIR-light-activatable {"}wireless{"} optogenetic tools, and we showed their ability to modulate cell signaling pathways in both mammalian cells and mice. We believe that these interesting NIR-light-responsive nanotechnologies will open new avenues for both basic research and clinical applications.",

author = "Yuanwei Zhang and Ling Huang and Zhanjun Li and Guolin Ma and Yubin Zhou and Gang Han",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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T1 - Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials

AU - Zhang, Yuanwei

AU - Huang, Ling

AU - Li, Zhanjun

AU - Ma, Guolin

AU - Zhou, Yubin

AU - Han, Gang

PY - 2016/4/26

Y1 - 2016/4/26

N2 - The regulation of cellular signaling in vivo has been a challenging task owing to the lack of effective methods for tunable control of the amplitude, location, and duration of cell-signaling events at a deep-tissue level. In this issue of ACS Nano, an intriguing paper by Ambrosone et al. demonstrates that deep-tissue-penetrating near-infrared (NIR) light can be used to control the Wnt/β-catenin-signaling pathway in a single-cell organism (Hydra) by utilizing microcapsules that contain plasmonic gold nanoparticles. In parallel, in recent work, we proposed upconversion nanoparticles (UCNPs) as NIR-light-activatable "wireless" optogenetic tools, and we showed their ability to modulate cell signaling pathways in both mammalian cells and mice. We believe that these interesting NIR-light-responsive nanotechnologies will open new avenues for both basic research and clinical applications.

AB - The regulation of cellular signaling in vivo has been a challenging task owing to the lack of effective methods for tunable control of the amplitude, location, and duration of cell-signaling events at a deep-tissue level. In this issue of ACS Nano, an intriguing paper by Ambrosone et al. demonstrates that deep-tissue-penetrating near-infrared (NIR) light can be used to control the Wnt/β-catenin-signaling pathway in a single-cell organism (Hydra) by utilizing microcapsules that contain plasmonic gold nanoparticles. In parallel, in recent work, we proposed upconversion nanoparticles (UCNPs) as NIR-light-activatable "wireless" optogenetic tools, and we showed their ability to modulate cell signaling pathways in both mammalian cells and mice. We believe that these interesting NIR-light-responsive nanotechnologies will open new avenues for both basic research and clinical applications.

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JO - ACS Nano

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Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials

Abstract

All Science Journal Classification (ASJC) codes

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