Imaging asynchronous mechanical activation of the paced heart with tagged MRI

Elliot R. McVeigh, Frits W. Prinzen, Bradley T. Wyman, Joshua E. Tsitlik, Henry R. Halperin, William C. Hunter

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


A method for imaging the rapid temporal-spatial evolution of myocardial deformations in the paced heart is proposed. High time resolution-tagged MR images were obtained after stimulation of the myocardium with an MR- compatible pacing system. The Images were analyzed to reconstruct dynamic models of local 3D strains over the entire left ventricle during systole. Normal canine hearts were studied in vivo with pacing sites on the right atrium, left ventricular free wall and right ventricular apex. This method clearly resolved local variations in myocardial contraction patterns caused by ventricular pacing. Potential applications are noninvasive determination of electrical conduction abnormalities and the evaluation of new pacing therapies.

Original languageEnglish (US)
Pages (from-to)507-513
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number4
StatePublished - Apr 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


  • Heart
  • MRI
  • Pacing
  • Tagging


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