Improved synthesis of the triazacryptand (TAC) and its application in the construction of a fluorescent TAC-BODIPY conjugate for K+ sensing in live cells

Binglin Sui, Xiling Yue, Michael G. Tichy, Taihong Liu, Kevin D. Belfield

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.

Original languageEnglish (US)
Pages (from-to)1189-1192
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number6
DOIs
StatePublished - Feb 2015

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • Cell imaging
  • Cryptands
  • Fluorescence
  • Potassium
  • Sensors

Fingerprint

Dive into the research topics of 'Improved synthesis of the triazacryptand (TAC) and its application in the construction of a fluorescent TAC-BODIPY conjugate for K+ sensing in live cells'. Together they form a unique fingerprint.

Cite this