Abstract
In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.
Original language | English (US) |
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Pages (from-to) | 1189-1192 |
Number of pages | 4 |
Journal | European Journal of Organic Chemistry |
Volume | 2015 |
Issue number | 6 |
DOIs | |
State | Published - Feb 2015 |
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry
Keywords
- Cell imaging
- Cryptands
- Fluorescence
- Potassium
- Sensors