TY - JOUR
T1 - Improving blend content uniformity via dry particle coating of micronized drug powders
AU - Huang, Zhonghui
AU - Xiong, Wannan
AU - Kunnath, Kuriakose
AU - Bhaumik, Sayani
AU - Davé, Rajesh N.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/6/15
Y1 - 2017/6/15
N2 - Content uniformity of low dose blends with fine active pharmaceutical ingredients (API) is adversely impacted due to API agglomeration caused by high powder cohesion. Dry coating using high-intensity vibratory mixing is employed to reduce API cohesion and granular Bond number as well as agglomeration as predicted by contact models, hence improve blend content uniformity (CU). Micronized acetaminophen (mAPAP) (~ 10 μm), a model API, was dry coated with nano-silica R972P (20 nm), and mixed with Avicel 102. The amount of silica was varied from 0 to 2.74 wt%, corresponding to theoretical surface area coverage (SAC) from 0 to 100% respectively. Bulk density, unconfined yield strength, and dispersive surface energy results indicated dry coating with 0.27 to 1.0 wt% silica was adequate for API property enhancement; further corroborated by improved CU for 5 wt% API blends. Excellent CU was achieved for 3, 5 and 10 wt% API loaded blends, where 30 min of mixing was found to be acceptable for all three. The CU with dry coated mAPAP was significantly lower and within the acceptable range as compared to control blends without silica, as well as those with silica added during blending. Sieving of mAPAP illustrated the reduction in mAPAP agglomeration, necessary for improved CU after dry coating, corroborating model based predictions. Compared to theoretical predictions, actual CU was higher unless API agglomerate size distribution obtained via sieving was taken into account. Overall, cohesion reduction by dry coating is shown as a promising approach for improving content uniformity of cohesive API blends.
AB - Content uniformity of low dose blends with fine active pharmaceutical ingredients (API) is adversely impacted due to API agglomeration caused by high powder cohesion. Dry coating using high-intensity vibratory mixing is employed to reduce API cohesion and granular Bond number as well as agglomeration as predicted by contact models, hence improve blend content uniformity (CU). Micronized acetaminophen (mAPAP) (~ 10 μm), a model API, was dry coated with nano-silica R972P (20 nm), and mixed with Avicel 102. The amount of silica was varied from 0 to 2.74 wt%, corresponding to theoretical surface area coverage (SAC) from 0 to 100% respectively. Bulk density, unconfined yield strength, and dispersive surface energy results indicated dry coating with 0.27 to 1.0 wt% silica was adequate for API property enhancement; further corroborated by improved CU for 5 wt% API blends. Excellent CU was achieved for 3, 5 and 10 wt% API loaded blends, where 30 min of mixing was found to be acceptable for all three. The CU with dry coated mAPAP was significantly lower and within the acceptable range as compared to control blends without silica, as well as those with silica added during blending. Sieving of mAPAP illustrated the reduction in mAPAP agglomeration, necessary for improved CU after dry coating, corroborating model based predictions. Compared to theoretical predictions, actual CU was higher unless API agglomerate size distribution obtained via sieving was taken into account. Overall, cohesion reduction by dry coating is shown as a promising approach for improving content uniformity of cohesive API blends.
KW - Cohesive API powder
KW - Content uniformity
KW - Dry coating
KW - Granular Bond number
KW - Low dose blends
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U2 - 10.1016/j.ejps.2017.04.012
DO - 10.1016/j.ejps.2017.04.012
M3 - Article
C2 - 28435077
AN - SCOPUS:85018918621
SN - 0928-0987
VL - 104
SP - 344
EP - 355
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
ER -