TY - JOUR
T1 - In situ activation of benzyl alcohols with XtalFluor-E
T2 - Formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel-Crafts benzylation
AU - Desroches, Justine
AU - Champagne, Pier Alexandre
AU - Benhassine, Yasmine
AU - Paquin, Jean François
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2015.
PY - 2015
Y1 - 2015
N2 - The Friedel-Crafts benzylation of arenes using benzyl alcohols activated in situ with XtalFluor-E is described. A wide range of 1,1-diarylmethanes and 1,1,1-triarylmethanes were prepared under experimentally simple and mild conditions, without the need for a transition metal or a strong Lewis acid. Notably, the reactivity observed demonstrates the potential of XtalFluor-E to induce C-OH bond ionization and SN1 reactivity of benzylic alcohols.
AB - The Friedel-Crafts benzylation of arenes using benzyl alcohols activated in situ with XtalFluor-E is described. A wide range of 1,1-diarylmethanes and 1,1,1-triarylmethanes were prepared under experimentally simple and mild conditions, without the need for a transition metal or a strong Lewis acid. Notably, the reactivity observed demonstrates the potential of XtalFluor-E to induce C-OH bond ionization and SN1 reactivity of benzylic alcohols.
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U2 - 10.1039/c4ob02655a
DO - 10.1039/c4ob02655a
M3 - Article
C2 - 25593020
AN - SCOPUS:84922762568
SN - 1477-0520
VL - 13
SP - 2243
EP - 2246
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 8
ER -