Magnetic Resonance Imaging (MRI) is a powerful medical diagnostic tool. Unfortunately, the loud noise produced during scanning is unpleasant and potentially harmful to patients and may limit imaging protocol. A variety of approaches have been proposed to reduce noise exposure. Prior studies have been conducted in a sound quality chamber to aid in the development and implementation of hardware, algorithms, and procedures, which resulted in an active noise cancellation system tailored to conditions present during MRI. The active noise control system generates a secondary sound signal fed into a set of headphones worn by the patient. This system performs well during physical simulation of scanning conditions. In this study, the headphones are worn by a dummy during in-situ MRI scanning. Our specific effort is to take a selected successful experiment under simulated conditions and repeat it during live scanning to evaluate the real time performance of the system conducted in-situ. Evaluation of a common scanning sequence was conducted and the procedure adjusted to maximize the performance of the system. The sound pressure levels (SPLs) at the patient's ear were measured with and without active control operational, and the results are compared to evaluate the active noise cancellation system's performance during live scans.