In vitro and in vivo evaluation of composite scaffolds for bone tissue engineering

Svetlana Schussler, Khadidiatou Guiro, Treena Livingston Arinzeh

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The repair of large bone defects resulting from trauma or disease remains a clinical challenge. Tissue engineering is a promising approach using scaffolds combined with cells and/or growth factors to simulate bone repair. Biocomposites, consisting of bioceramics and synthetic and/or natural polymers, have been sought for use as scaffolds because of their attractive properties in accelerating bone tissue formation. Bioceramics have proven osteoconductivity and can be combined with various types of polymers to create highly porous biocomposite scaffolds. This chapter will review bioceramic and polymer compositions used in composite scaffolds, their design, and their evaluation in in vitro and in vivo studies, demonstrating their potential for use in bone repair.

Original languageEnglish (US)
Title of host publicationHandbook of Bioceramics and Biocomposites
PublisherSpringer International Publishing
Number of pages22
ISBN (Electronic)9783319124605
ISBN (Print)9783319124599
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Materials Science
  • General Medicine
  • General Dentistry


  • Bioceramics
  • Biocomposites
  • Bone tissue engineering
  • Scaffolds


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