In vitro and in vivo evaluation of composite scaffolds for bone tissue engineering

Svetlana Schussler; Khadidiatou Guiro; Treena Livingston Arinzeh

doi:10.1007/978-3-319-12460-5_39

In vitro and in vivo evaluation of composite scaffolds for bone tissue engineering

Svetlana Schussler, Khadidiatou Guiro, Treena Livingston Arinzeh

Bio-Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The repair of large bone defects resulting from trauma or disease remains a clinical challenge. Tissue engineering is a promising approach using scaffolds combined with cells and/or growth factors to simulate bone repair. Biocomposites, consisting of bioceramics and synthetic and/or natural polymers, have been sought for use as scaffolds because of their attractive properties in accelerating bone tissue formation. Bioceramics have proven osteoconductivity and can be combined with various types of polymers to create highly porous biocomposite scaffolds. This chapter will review bioceramic and polymer compositions used in composite scaffolds, their design, and their evaluation in in vitro and in vivo studies, demonstrating their potential for use in bone repair.

Original language	English (US)
Title of host publication	Handbook of Bioceramics and Biocomposites
Publisher	Springer International Publishing
Pages	615-636
Number of pages	22
ISBN (Electronic)	9783319124605
ISBN (Print)	9783319124599
DOIs	https://doi.org/10.1007/978-3-319-12460-5_39
State	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

General Engineering
General Materials Science
General Medicine
General Dentistry

Keywords

Bioceramics
Biocomposites
Bone tissue engineering
Scaffolds

Access to Document

10.1007/978-3-319-12460-5_39

Cite this

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abstract = "The repair of large bone defects resulting from trauma or disease remains a clinical challenge. Tissue engineering is a promising approach using scaffolds combined with cells and/or growth factors to simulate bone repair. Biocomposites, consisting of bioceramics and synthetic and/or natural polymers, have been sought for use as scaffolds because of their attractive properties in accelerating bone tissue formation. Bioceramics have proven osteoconductivity and can be combined with various types of polymers to create highly porous biocomposite scaffolds. This chapter will review bioceramic and polymer compositions used in composite scaffolds, their design, and their evaluation in in vitro and in vivo studies, demonstrating their potential for use in bone repair.",

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AU - Schussler, Svetlana

AU - Guiro, Khadidiatou

AU - Arinzeh, Treena Livingston

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AB - The repair of large bone defects resulting from trauma or disease remains a clinical challenge. Tissue engineering is a promising approach using scaffolds combined with cells and/or growth factors to simulate bone repair. Biocomposites, consisting of bioceramics and synthetic and/or natural polymers, have been sought for use as scaffolds because of their attractive properties in accelerating bone tissue formation. Bioceramics have proven osteoconductivity and can be combined with various types of polymers to create highly porous biocomposite scaffolds. This chapter will review bioceramic and polymer compositions used in composite scaffolds, their design, and their evaluation in in vitro and in vivo studies, demonstrating their potential for use in bone repair.

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KW - Biocomposites

KW - Bone tissue engineering

KW - Scaffolds

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ER -

In vitro and in vivo evaluation of composite scaffolds for bone tissue engineering

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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