In Vitro Photodynamic Studies of a BODIPY-Based Photosensitizer

Bosung Kim, Binglin Sui, Xiling Yue, Simon Tang, Michael G. Tichy, Kevin D. Belfield

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A new halogenated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative was designed as a singlet-oxygen photosensitizer (PS) for use as a photodynamic therapy (PDT) agent, and its photophysical properties were characterized. The PS, having two iodine atom substituents, exhibited a low fluorescence quantum yield (ΦFL) of 0.02 and high singlet-oxygen-generation quantum yield (ΦΔ) of 0.93. Furthermore, in vitro photodynamic activities were evaluated to assess the potential of using the PS for PDT. A propidium iodide (PI) fluorescence assay and live-cell imaging of Lewis lung carcinoma (LLC) cells demonstrated that the cellular damage is induced by the photosensitization of the BODIPY dye, which subsequently leads to cell death by necrosis.q.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number1
DOIs
StatePublished - Jan 3 2017

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • BODIPY
  • Boron
  • Dyes/Pigments
  • Photodynamic therapy
  • Photosensitizer
  • Singlet oxygen

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