Increasing drug release rate through foamed structures

Graciela Terife, Niloufar Faridi, Costas G. Gogos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The influence of foam morphology on the release rate of Indomethacin (INM) from a solid solution prepared by hot melt extrusion was investigated. Closed cell foams were produced through a batch process, employing CO 2 as physical blowing agent. In all cases foamed disks showed faster INM's release than un-foamed disks. The time required for completing INM's release was reduced up to 75% mainly due to extensive and random breakage of the sample during dissolution test.

Original languageEnglish (US)
Title of host publication70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
Pages1784-1790
Number of pages7
StatePublished - Sep 11 2012
Event70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012 - Orlando, FL, United States
Duration: Apr 2 2012Apr 4 2012

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume3

Other

Other70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
CountryUnited States
CityOrlando, FL
Period4/2/124/4/12

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

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