Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction

Zhize Yuan, Yung Hao Tsou, Xue Qing Zhang, Shixing Huang, Yang Yang, Mingzhu Gao, William Ho, Qiang Zhao, Xiaofeng Ye, Xiaoyang Xu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Implanted medical biomaterials are closely in contact with host biological systems via biomaterial-cell/tissue interactions, and these interactions play pivotal roles in regulating cell functions and tissue regeneration. However, many biomaterials degrade over time, and these degradation products also have been shown to interact with host cells/tissue. Therefore, it may prove useful to specifically design implanted biomaterials with degradation products which greatly improve the performance of the implant. Herein, we report an injectable, citrate-containing polyester hydrogel which can release citrate as a cell regulator via hydrogel degradation and simultaneously show sustained release of an encapsulated growth factor Mydgf. By coupling the therapeutic effect of the hydrogel degradation product (citrate) with encapsulated Mydgf, we observed improved postmyocardial infarction (MI) heart repair in a rat MI model. Intramyocardial injection of our Mydgf-loaded citrate-containing hydrogel was shown to significantly reduce scar formation and infarct size, increase wall thickness and neovascularization, and improve heart function. This bioactive injectable hydrogel-mediated combinatorial approach offers myriad advantages including potential adjustment of delivery rate and duration, improved therapeutic effect, and minimally invasive administration. Our rational design combining beneficial degradation product and controlled release of therapeutics provides inspiration toward the next generation of biomaterials aiming to revolutionize regenerative medicine.

Original languageEnglish (US)
Pages (from-to)38429-38439
Number of pages11
JournalACS Applied Materials and Interfaces
Volume11
Issue number42
DOIs
StatePublished - Oct 23 2019

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Keywords

  • Mydgf
  • cardiac remodeling
  • injectable hydrogel
  • myocardial infarction (MI)
  • protein delivery

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