Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on Incisional Pain and Neuropathic Pain

Xue Tian, He Zhu, Shibin Du, Xue Qing Zhang, Fuqing Lin, Fengtao Ji, Yung Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan Xiang Tao

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The management of persistent postsurgical pain and neuropathic pain remains a challenge in the clinic. Local anesthetics have been widely used as simple and effective treatment for these 2 disorders, but the duration of their analgesic effect is short. We here reported a new poly lactic-co-glycolic acid (PLGA)-coated ropivacaine that was continuously released in vitro for at least 6 days. Perisciatic nerve injection of the PLGA-coated ropivacaine attenuated paw incision-induced mechanical allodynia and heat hyperalgesia during the incisional pain period, and spared nerve injury-induced mechanical and cold allodynia for at least 7 days postinjection. This effect was dose-dependent. Perisciatic nerve injection of the PLGA-coated ropivacaine did not produce detectable inflammation, tissue irritation, or damage in the sciatic nerve and surrounding muscles at the injected site, dorsal root ganglion, spinal cord, or brain cortex, although the scores for grasping reflex were mildly and transiently reduced in the higher dosage-treated groups. Perspective: Given that PLGA is an FDA-approved medical material, and that ropivacaine is used currently in clinical practice, the injectable PLGA-coated ropivacaine represents a new and highly promising avenue in the management of postsurgical pain and neuropathic pain.

Original languageEnglish (US)
Pages (from-to)180-195
Number of pages16
JournalJournal of Pain
Volume22
Issue number2
DOIs
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Keywords

  • Microparticles
  • long-lasting analgesia
  • neuropathic pain
  • poly lactic-co-glycolic acid
  • postsurgical pain
  • ropivacaine

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