Injectable polyester hydrogel-mediated myeloid-derived growth factor delivery for improved post myocardial infarction heart healing

Zhongyu Li, Xiaoyang Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Cardiac dysfunction, specifically myocardial infarction (MI) ranks among the major causes of morbidity and mortality in current times. Intramyocardial therapeutics injection is an efficient method of enhancing cardiac performance after experiencing ischemic MI. Myeloid-derived growth factor (Mydgf) is a newly found protein secreted by bone marrow-derived monocytes and macrophages. It is responsible for cardiac myocyte survival, angiogenesis, and shows promise in promoting cardiac recovery after MI. Additionally, Mydgf shows angiogenic activity by motivating the migration and tubular formation of human umbilical vessel endothelial cells (HUVECs). Moreover, Mydgf has been shown to protect cardiomyocytes from apoptosis. However, in order to maintain the protein level, several days of continuous perfusion is needed, which severely limits the clinical translation of this protein. Here, we introduce an injectable polyester hydrogel which is capable of loading Mydgf with an extended release capability in vivo and demonstrate an innovative new potential treatment of MI. Methods: Citrate acid was reacted with hexaethylene.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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