Injectable self-assembling peptide hydrogels for tissue writing and embryonic stem cell culture

Pamela Hitscherich, Peter K. Nguyen, Adithya Kannan, Anthony Chirayath, Sugosh Anur, Biplab Sarkar, Eun Jung Lee, Vivek A. Kumar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The fabrication of extracellular matrix-mimic hydrogels that can nurture and direct differentiation of embryonic stem cells is an important target for pattern-printed tissue replacement. Another desirable feature for such materials is their ability to be injected and recover their rheological features post-injection, allowing for facile non-invasive implantation. In this report, we demonstrate the ability of a self-assembling peptide hydrogel to support the culture of embryonic stem cells with the potential to direct differentiation. We also show that we can write a functional tissue replacement with a predetermined pattern using our formulation. Our results may lead to in vivo replacement of diseased tissue with a spatially resolved pattern of a regenerative hydrogel.

Original languageEnglish (US)
Pages (from-to)802-807
Number of pages6
JournalJournal of Biomedical Nanotechnology
Volume14
Issue number4
DOIs
StatePublished - Apr 2018

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Keywords

  • Cell injection
  • Embryonic stem cells
  • Injectable hydrogel
  • Self-Assembling peptide
  • Tissue mimic

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