INTEGRATED BIOREACTOR-SEPARATOR: IN SITU RECOVERY OF FERMENTATION PRODUCTS BY A NOVEL MEMBRANE-BASED DISPERSION-FREE SOLVENT EXTRACTION TECHNIQUE.

G. T. Frank, K. K. Sirkar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

43 Scopus citations

Abstract

The authors demonstrate here a locally integrated-bioreactor-separator for the recovery of fermentation products. The tubular bioreactor-separator contains a large number of axially located microporous hydrophobic hollow fiber membranes evenly distributed amongst immobilized biocatalyst particles. Nutrients are supplied to the biocatalyst as in an immobilized cell tubular reactor. A solvent, dibutyl phthalate, flows through the hollow fiber lumina and continuously extracts the products produced locally in the fermentor using a dispersion-free solvent extraction technique recently developed at Stevens. Carbon dioxide is also removed continuously throughout the length of the fibers ensuring greater reactor stability. Additionally the hollow fibers were used to supply oxygen throughout the reactor, while removing CO//2. Production of ethanol by yeast fermentation is considered and data presented.

Original languageEnglish (US)
Title of host publicationBiotechnology and Bioengineering Symposium
EditorsCharles D. Scott
PublisherJohn Wiley & Sons
Pages303-316
Number of pages14
Edition17
ISBN (Print)0471627623
StatePublished - Dec 1 1986
Externally publishedYes

Publication series

NameBiotechnology and Bioengineering Symposium
Number17
ISSN (Print)0572-6565

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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