Integrating waveguide biosensor

Frances S. Ligler, Marc Breimer, Joel P. Golden, Delana A. Nivens, James P. Dodson, Tiffanee M. Green, Daniel P. Haders, Omowunmi A. Sadik

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


A capillary biosensor is demonstrated which uses the waveguiding properties of the capillary to integrate the signal over an increased surface area without simultaneously increasing the background noise from the detector. This biosensor achieves limits of detection of 30-50 pg/mL in immunoassays using a diode laser for excitation and a PMT for detection. This is ∼2 orders of magnitude greater sensitivity than was achieved using the same immunoassay reagents in a fiber optic biosensor or a planar array biosensor. Two different approaches to using the capillaries as immunosensors are described, either of which could be adapted for multianalyte sensing.

Original languageEnglish (US)
Pages (from-to)713-719
Number of pages7
JournalAnalytical Chemistry
Issue number3
StatePublished - Feb 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


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