Integration of electrospinning and 3D bioprinting for fibrous tissue manufacturing

Electrospinning has been established for generating nanofibrous scaffolds that structurally mimic the native extracellular matrix (ECM). Biomimetic electrospun fibers can be used for cell culture, drug delivery, and wound healing. This review surveys the current electrospinning methodologies, focusing on solvent-free and multi-nozzle techniques. We analyze key operational and material parameters that dictate the functional properties of the resulting nanofiber constructs. We establish a correlation between these electrospinning parameters and existing bioprinting methodologies, identifying specific integration points to enhance the biological performance of electrospun scaffolds. We detail the pivotal bioprinting parameters required for successful scaffold integration and subsequent biofabrication. This manuscript offers a roadmap for selecting bioinks and cell compositions to optimize outcomes in engineered tissue constructs and implants.