TY - JOUR
T1 - Interactions of nanomaterials and biological systems
T2 - Implications to personalized nanomedicine
AU - Zhang, Xue Qing
AU - Xu, Xiaoyang
AU - Bertrand, Nicolas
AU - Pridgen, Eric
AU - Swami, Archana
AU - Farokhzad, Omid C.
N1 - Funding Information:
This work was supported by the National Institutes of Health (NIH) (grant CA151884 ), the National Heart, Lung, and Blood Institute , (NIH), through a Program of Excellence in Nanotechnology (PEN) Award , (contract # HHSN268201000045C ) and the David Koch-Prostate Cancer Foundation Award in Nanotherapeutics . Dr. Xiaoyang Xu acknowledges postdoctoral support from an NIH National Research Service Award (NRSA) ( 1F32CA168163-01 ). Dr. Nicolas Bertrand acknowledges a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR) . Dr. Farokhzad declares financial interests in BIND Biosciences, Selecta Biosciences and Blend Therapeutics. The rest of the authors declare no conflict of interest.
PY - 2012/10
Y1 - 2012/10
N2 - The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to design flexibility, small sizes, large surface-to-volume ratio, and ease of surface modification with multivalent ligands to increase avidity for target molecules. Nanomaterials can be engineered to interact with specific biological components, allowing them to benefit from the insights provided by personalized medicine techniques. To tailor these interactions, a comprehensive knowledge of how nanomaterials interact with biological systems is critical. Herein, we discuss how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes. A general overview of nanomaterials under investigation is provided with an emphasis on systems that have reached clinical trials. Finally, considerations for the development of personalized nanomedicines are summarized such as the potential toxicity, scientific and technical challenges in fabricating them, and regulatory and ethical issues raised by the utilization of nanomaterials.
AB - The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to design flexibility, small sizes, large surface-to-volume ratio, and ease of surface modification with multivalent ligands to increase avidity for target molecules. Nanomaterials can be engineered to interact with specific biological components, allowing them to benefit from the insights provided by personalized medicine techniques. To tailor these interactions, a comprehensive knowledge of how nanomaterials interact with biological systems is critical. Herein, we discuss how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes. A general overview of nanomaterials under investigation is provided with an emphasis on systems that have reached clinical trials. Finally, considerations for the development of personalized nanomedicines are summarized such as the potential toxicity, scientific and technical challenges in fabricating them, and regulatory and ethical issues raised by the utilization of nanomaterials.
KW - In vivo imaging
KW - Molecular diagnostic
KW - Nanomaterials
KW - Nanoparticles
KW - Nanotechnology
KW - Personalized nanomedicine
KW - Protein binding
KW - Receptor-mediated endocytosis
KW - Targeted delivery
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U2 - 10.1016/j.addr.2012.08.005
DO - 10.1016/j.addr.2012.08.005
M3 - Review article
C2 - 22917779
AN - SCOPUS:84867650550
SN - 0169-409X
VL - 64
SP - 1363
EP - 1384
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 13
ER -